Reducing the onward spread of mpox requires a tailored approach based on an understanding of the behaviours and contexts of the affected communities—at this time gay, bisexual and other men who have sex with men (MSM) with multiple, recent sexual partners, as well as the health workers who engage with these groups. Behavioural and cultural insights can help promote a people-centred process where mpox-related policies, services and communication are shaped by and respond to the needs, perspectives and conditions of those most involved and affected.